Effect of Iron Supplementation on Oxidative Stress and Antioxidant Status in Iron-Deficiency Anemia
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Humana Press Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glutathione peroxidase (GSH-Px), and the activities of superoxide dismutase (SOD) and catalase in 63 patients with iron-deficiency anemia before and after 6 wk of iron supplementation and at the time when body iron stores are saturated. After 6 wk of iron supplementation, a significant decrease of oxidative stress was observed in the treated subjects relative to controls (p<0.05). No significant differences existed between treated patients at 6 wk and at the end of the study. The erythrocyte levels of catalase, SOD, and GSH-Px were significantly lower in treated patients relative to controls (p<0.05). These levels increased after 6 wk of supplementation (p<0.05) and showed no significant differences with those at the end of the study.
Açıklama
Anahtar Kelimeler
İron-Deficiency Anemia, İron Replacement, Oxidative Stress, Antioxidants
Kaynak
Biological Trace Element Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
96
Sayı
Künye
Kurtoğlu, E., Uğur, A., Baltacı, A. K., Ündar, L., (2003). Effect of Iron Supplementation on Oxidative Stress and Antioxidant Status in Iron-Deficiency Anemia. Biological Trace Element Research, (96), 117-123. Doi: 10.1385/BTER:96:1-3:117
