Serum Interleukin-8 Levels May Predict Relapse in Brucellosis
Yükleniyor...
Dosyalar
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: To investigate whether cytokines are effective in predicting relapses among patients with acute brucellosis. Materials and methods: This trial was conducted in 42 patients who were being followed-up with diagnosis of acute brucellosis. Serum samples were obtained on days 0 and 45. In patients whose clinical symptoms recurred within a year of treatment and exhibited infectious parameters in compliance with brucellosis, a Rivanol standard tube agglutination (STA) test was performed and the diagnosis of relapse was based on brucella immunoglobulin M (IgM). Serum samples were evaluated for various parameters, namely tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin 2 (IL-2), IL-4, IL-6, IL-8, IL-10, and soluble IL-2 receptor (sIL-2R). Results: Relapse was seen in 7 patients. No difference was found between relapsing patients (RPs) and fully recovered patients (FRPs) in terms of age, sex, leukocyte levels, or C-reactive protein (CRP) values. Comparison of TNF alpha, IFN gamma, IL-2, IL-4, IL-6, IL-8, and IL-10 values on day 0 (day of enrollment) revealed 2-fold higher IL-8 values among RPs compared to FRPs. IL-8 was suggested as significant in terms of predicting relapse. Conclusion: Diagnosis and treatment of relapsing cases in acute brucellosis have not yet been clarified. Predicting relapse by certain laboratory evaluations may be beneficial in preventing clinical relapses by rearranging treatment and monitoring strategies of patients.
Açıklama
Anahtar Kelimeler
Acute brucellosis, relapse, cytokines
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
42
Sayı
5
Künye
Aktuğ Demir, N., Ural, O., (2012). Serum Interleukin-8 Levels May Predict Relapse in Brucellosis. Turkish Journal of Medical Sciences, 42(5), 796-801. Doi:10.3906/sag-1107-60
