The role of intravenous immunoglobulin in the treatment of cerebral vasospasm induced by subarachnoid haemorrhage: An experimental study

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dc.contributor.authorCengiz, Sahika Liva
dc.contributor.authorErdi, Mehmet Fatih
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorTosun, Murat
dc.contributor.authorUstun, Mehmet Erkan
dc.contributor.authorGokce, Recep
dc.contributor.authorYosunkaya, Alper
dc.date.accessioned2020-03-26T18:17:14Z
dc.date.available2020-03-26T18:17:14Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to determine whether intravenous immunoglobulin (IVIG) prevents cerebral vasospasm in rabbits with induced subarachnoid haemorrhage (SAH). The effect of IVIG on apoptosis in the endothelial cells of the basilar artery was also evaluated. Methods: Eighteen New Zealand white rabbits were allocated randomly into three groups. SAH was induced by injecting autologous blood into the cisterna magna. Group 1, the control group, was subjected to sham surgery (no induction of SAH). Group 2 had SAH alone and Group 3 had SAH plus IVIG. Three days after treatment, the animals were sacrificed. The basilar artery tissues were analysed histologically and the malondialdehyde levels in the brain stem tissues were evaluated biochemically. Results: Differences in the histopathological luminal areas and full wall thicknesses in the SAH plus IVIG group and the SAH group were statically insignificant (p > 0.005). The malondialdehyde level was also found to be lower in the IVIG group than in the SAH group, although this difference was not significant (p > 0.005). Conclusion: Although the IVIG treatment was revealed to have no vasodilator effect on the SAH-induced spastic basilar artery, it was shown to have a beneficial effect on the apoptosis of endothelial cells, probably via anti-inflammatory mechanisms.en_US
dc.identifier.doi10.3109/02699052.2011.589793en_US
dc.identifier.endpage971en_US
dc.identifier.issn0269-9052en_US
dc.identifier.issn1362-301Xen_US
dc.identifier.issue10en_US
dc.identifier.pmid21745175en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage965en_US
dc.identifier.urihttps://dx.doi.org/10.3109/02699052.2011.589793
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26999
dc.identifier.volume25en_US
dc.identifier.wosWOS:000293464800006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBRAIN INJURYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnimal modelsen_US
dc.subjecttherapyen_US
dc.subjectpreventionen_US
dc.subjectefficacyen_US
dc.subjecthead injuryen_US
dc.titleThe role of intravenous immunoglobulin in the treatment of cerebral vasospasm induced by subarachnoid haemorrhage: An experimental studyen_US
dc.typeArticleen_US

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