Phytochemical Analyses and Pharmacological Screening of Neem Oil

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dc.authorid0000-0002-8901-6484
dc.contributor.authorCesa, Stefania
dc.contributor.authorSisto, Francesca
dc.contributor.authorZengin, Gökhan
dc.contributor.authorScaccabarozzi, Diletta
dc.contributor.authorKokolakis, Antonios K.
dc.contributor.authorScaltrito, Maria Maddalena
dc.contributor.authorGrande, Rossella
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCacciagrano, Francesco
dc.contributor.authorAngiolella, Letizia
dc.contributor.authorCampestre, Cristina
dc.contributor.authorGranese, Arianna
dc.contributor.authorChimenti, Paola
dc.contributor.authorBasilico, Nicoletta
dc.date.accessioned2020-03-26T20:19:08Z
dc.date.available2020-03-26T20:19:08Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractAn Italian certified Neemseed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several Candida spp. and Malassezia furfur strains and antiprotozoal activity against Plasmodium falciparum, Leishmania infantum and Leishmania tropica were performed. Neemseed oil demonstrated low toxicity and a great inhibitory efficacy against tyrosinase and lipase enzymes. Antimalarial and anti-leishmanial activities were also demonstrated, but weak or no activity was evidenced against Helicobacter pylori, Candida and Malassezia strains. Overall, these findings encourage the potential use of this natural product in some disease treatments and justify its use in traditional medicine. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipG. d'Annunzio University of Chieti-Pescara (FAR 2017)en_US
dc.description.sponsorshipThis work was supported by local grants from "G. d'Annunzio" University of Chieti-Pescara (FAR 2017).en_US
dc.identifier.citationCesa, S., Sisto, F., Zengin, G., Scaccabarozzi, D., Kokolakis, A. K., Scaltrito, M. M., Grande, R., Locatelli, M., Cacciagrona, F., Angiolella, L., Campestre, C., Granese, A., Chimenti, P., Basilico, N. (2019). Phytochemical analyses and Pharmacological Screening of Neem Oil. South African Journal of Botany, 120, 331-337. doi: https://dx.doi.org/10.1016/j.sajb.2018.10.019
dc.identifier.doi10.1016/j.sajb.2018.10.019en_US
dc.identifier.endpage337en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2018.10.019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38103
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600046en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectColor analysisen_US
dc.subjectHPLC-PDAen_US
dc.subjectH. pylorien_US
dc.subjectNeem oilen_US
dc.subjectMalariaen_US
dc.subjectLeishmaniaen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectEnzim inhibisyonu
dc.subjectNeem yağı
dc.titlePhytochemical Analyses and Pharmacological Screening of Neem Oilen_US
dc.typeArticleen_US

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