Cholinesterase, ?-glucosidase, ?-amylase, and tyrosinase inhibitory effects and antioxidant activity of veronica officinalis extracts

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dc.authorid0000-0002-4674-7009
dc.authorid0000-0001-6327-4779
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorUçar, Esra
dc.date.accessioned2020-03-26T19:52:37Z
dc.date.available2020-03-26T19:52:37Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractIn this study, inhibition ability of Veronica officinalis extracts against Alzheimer’s disease-related enzymesacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), diabetes mellitus related enzymes ?-glucosidase and ?-amylase and antioxidant of Veronica officinalis were investigated. To the best of our knowledge, there are no previous studieson the enzyme inhibition activities of the V. officinalis extracts. For this aim, V. officinalis extracted with methanol and waterby maceration method and their antioxidant activities were evaluated by DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS [2,2?-Azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid)] radical scavenging assays, total phenol, total flavonoid content, ironchelating and ferric reducing power assays. The enzyme inhibition activity was performed with 96-well plate method.According to the obtained results; the plant extracts have good antioxidant effects. In the same time, the water extract havestronger inhibition activity against AChE, BuChE and ?-glucosidase, ?-amylase, and tyrosinase than methanol extract. Theexperimental findings indicated that the water extract exerted the higher ?-glucosidase, ?-amylase and tyrosinase (82.07 2.91, 63.61 3.93 and 47.47 0.53 at 2 mg mL -1 , respectively) inhibition than reference drugs. The obtained resultsdemonstrate that this plant has a significant potential for improving pharmaceutical formulations.en_US
dc.identifier.citationEruygur, N., Uçar, E. (2018). Cholinesterase, α-Glucosidase, α-Amylase, and Tyrosinase Inhibitory Effects and Antioxidant Activity of Veronica officinalis Extracts. Türkiye Tarımsal Araştırmalar Dergisi, 5(3), 253-259.
dc.identifier.doi10.19159/tutad.425732en_US
dc.identifier.endpage259en_US
dc.identifier.issn2148-2306en_US
dc.identifier.issn2528-858Xen_US
dc.identifier.issue3en_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://dx.doi.org/10.19159/tutad.425732
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TXpBNE56QTFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36214
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEruygur, Nuraniye
dc.language.isoenen_US
dc.relation.ispartofTürkiye Tarımsal Araştırmalar Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectalzheimer’s
dc.subjectdiabetes
dc.titleCholinesterase, ?-glucosidase, ?-amylase, and tyrosinase inhibitory effects and antioxidant activity of veronica officinalis extractsen_US
dc.typeArticleen_US

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