Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys
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Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to determine whether the magnitude of the intraocular-pressure (IOP)-lowering response in monkeys to the nonselective prostaglandin (PG)F2a-isopropyl ester (ie) can be reproduced by combining other PG-subtype-selective compounds. IOP was lowered by approximately 25% after 4-5 days of topical administration with latanoprost (FP agonist, 1.5 ?g, q.d.), bimatoprost (prostamide, whose metabolites have been shown to be FP agonists; 9 ?g, q.d.), or travoprost (FP agonist, 1.2 ?g, q.d) or the EP2 agonist, butaprost (25 ?g, b.i.d.). The EP1 agonist, 17-phenyl trinor (PhT) PGE2 (b.i.d.), and EP3 agonist, sulprostone (b.i.d.), had no IOP-lowering effects. The addition of butaprost, sulprostone (10 ?g), or 17PhTPGE2 (25 ?g) to latanoprost did not lower IOP more than latanoprost alone. However, treatment with the combination of latanoprost, 17PhTPGE2, butaprost, and sulprostone produced a similar 50-55% reduction in IOP, as did PGF 2?-ie (b.i.d.). In conclusion, latanoprost, travoprost, and bimatoprost produce similar IOP-lowering responses in normotensive monkeys and are most efficacious when administered q.d. pm, compared to b.i.d. The combination of the FP, EP1, EP2, and EP3 agonists used in this study was sufficient to lower IOP by the same magnitude as PGF2?-ie, suggesting that combining PG-subtype agonists may be a potent antiglaucoma strategy.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Ocular Pharmacology and Therapeutics
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
25
Sayı
1
Künye
Gabelt, B. T., Hennes, E. A., Bendel, M. A., Constant, C. E., Okka, M., Kaufman, P. L., (2009). Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys. Journal of Ocular Pharmacology and Therapeutics, 25(1), 1-8. Doi: 10.1089/jop.2008.0089
