Aumeeruddy-Elalfi, ZaahiraIsmael, Ismael SaidHosenally, MuzzammilZengin, GökhanMahomoodally, Mohamad Fawzi2020-03-262020-03-2620182190-572X2190-5738https://dx.doi.org/10.1007/s13205-018-1413-xhttps://hdl.handle.net/20.500.12395/36591The biofilm inhibition and eradication potential of essential oils (EOs) extracted from six tropical medicinal herbs and food plants [Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), Citrus reticulata (CR), and Cinnamomum zeylanicum (CZ)] were assessed. The mechanism of inhibition was studied via quenching of efflux pump. Cytotoxicity was evaluated using Artemia sauna assay and cell lines [human cervix carcinoma (HeLa), human lung fibroblast (MRC-5), and murine melanoma (B16F10)]. EOs of CH, CR, PA, and PT were found to be prospective antibiofilm agents (IC50 of 0.29, 0.59, 0.22, and 0.11 mg/mL against Staphylococcus epidermidis; 0.39, 0.54, 0.09, and 0.13 mg/mL against Escherichia coli; and 0.54, 0.90, 0.44 and 0.51 mg/mL against Candida albicans for CH, CR, PA, and PT, respectively). The simultaneous actions of the EOs and efflux pump inhibitor impacted on the resistance of the biofilms. LC50 of the EOs ranged from 223 to 583 mg/mL against A. salina. The non-cytotoxic concentration of the EOs varied from 200 to 300 mu g/mL (HeLa and MRC-5), and 150-200 mu g/mL (B16F10). EOs from these tropical medicinal herbs and food plants are useful sources of new antimicrobials with low cytotoxicity which could open new horizons in the drug development process.en10.1007/s13205-018-1413-xinfo:eu-repo/semantics/openAccessAntibacterial activityCytotoxicityHerbal medicineEssential oilsMedicinal plantsTraditional medicineEfflux pump inhibitorArticle8930221108Q2WOS:000443529500002Q3