Üstün, Mehmet ErkanDuman, AteşÖğün, Cemile ÖztinSümer, FatihGürbilek, Mehmet2020-03-262020-03-262001Üstün, M. E., Duman, A., Öğün, C. Ö., Sümer, F., Gürbilek, M., (2001). Effects of Deferoxamine on Tissue Superoxide Dismutase and Glutathione Peroxidase Levels in Experimental Head Trauma. Journal of Trauma-Injury Infection and Critical Care, 51(1), 22-25. Doi:10.1097/00005373-200107000-000040022-52821529-8809https://dx.doi.org/10.1097/00005373-200107000-00004https://hdl.handle.net/20.500.12395/1753560th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma -- OCT 11-15, 2000 -- SAN ANTONIO, TXBackground: This study aims to evaluate the effects of deferoxamine on tissue superoxide dismutase (SOD) and glutathione peroxidase (GPx) brain levels after head trauma. Methods: Thirty rabbits were divided equally into three groups: group 1 was the sham-operated group, group 2 suffered head trauma (no treatment was given), and group 3 received deferoxamine 50 mg/kg after the trauma. Head trauma was applied unilaterally. One hour after trauma, brain cortices were resected and SOD and GPx levels were determined. One-way analysis of variance and Tukey-HSD tests were used for analysis. Significance was defined asp < 0.05. Results: Baseline SOD levels are preserved in the traumatized side of the deferoxamine-treated group. Although GPx level of the traumatized side of the deferoxamine-treated group decreased significantly, the decrease was significantly less than the nontreated group. Conclusion: Trauma leads to a decrease in brain tissue SOD and GPx levels, Deferoxamine suppresses this decrease completely in SOD level and partially in GPx level when given after trauma.en10.1097/00005373-200107000-00004info:eu-repo/semantics/openAccessDeferoxamineGlutathione PeroxidaseHead TraumaSuperoxide DismutaseArticle511222511468462WOS:000169905800005N/A