Tuncer, SemaPirbudak, LütfiyeBalat, ÖzcanCapar, M.2020-03-262020-03-262003Tuncer, S., Pirbudak, L., Balat, Ö., Capar, M., (2003). Adding Ketoprofen to Intravenous Patient-Controlled Analgesia With Tramadol After Major Gynecological Cancer Surgery: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial. European Journal of Gynaecological Oncology, 24(2), 181-184.0392-2936https://hdl.handle.net/20.500.12395/18361Ketoprofen is a NSAIDs of the 2-aryl propionic acid class commonly used in the treatment of inflammatory rheumatic disease, acute pain and fever. Clinically, ketoprofen seems to reduce morphine requirements by 33 to 40% with ketoprofen's supposed central mechanism of analgesia. We evaluated the efficacy and safety of intravenous (IV) ketoprofen as an adjuvant to IV PCA (patient con- trolled analgesia) with tramadol after major gynecological cancer surgery for postoperative analgesia. Fifty patients were enrolled in this double-blinded, randomized, placebo-controlled study. Patients were allocated randomly to two groups: group I (25 patients) served as a control group, with patients receiving saline; group II (25 patients) received ketopro- fen. Patients received an intravenous bolus of saline or 100 mg ketoprofen at the end of surgery. Then, PCA was given as a 20 mg tramadol bolus and 10 min lockout time. Pain relief was regularly assessed using a visual analog scale. Tramadol consumption, side effects, and patient satisfaction were noted during the 24 hours after the surgery. No significant difference was observed in pain score, side-effects and patient satisfaction between the groups (p > 0.05). The cumulative PCA-tramadol consumption was lower in the ketoprofen-treated patients than placebo-treated patients (p < 0.05). Our results demonstrate that a single dose of 100 mg ketoprofen reduced tramadol consumption for treatment of postoperative pain after major gynecological cancer surgery.eninfo:eu-repo/semantics/openAccessketoprofentramadolpostoperative painPCAmajor gynecological surgeryArticle24218118412701975N/AWOS:000182102800020Q4