Dogan, Hasan HuseyinDuman, RustemTuncer, Pinar2020-03-262020-03-2620180975-8232https://dx.doi.org/10.13040/IJPSR.0975-8232.9(12).5240-45https://hdl.handle.net/20.500.12395/36537Antiviral properties of methanol and aqueous extracts from Morchella conica and Fomes fomentarius were assessed by colorimetric XTT test against human respiratory syncytial virus (HRSV). HEp-2 cell line was used for the cytotoxic and antiviral effects of the extracts. Non-cytotoxic concentrations of methanol and aqueous extracts of M. conica were tested in 50000 to 195 mu g/mL. In contrast, the cytotoxic F. fomentarius methanol and aqueous extracts and Ribavirin were tested at concentrations from 3347-13.1 mu g/mL, 4906.5-19.2 mu g/mL and 86.60-0.30 mu g/mL, respectively. The results showed that aqueous extract of F. fomentarius had strong anti-HRSV activity (EC50 = 358.7 mu g/mL, SI = 27.4) which could be compared with ribavirin (EC50 = 15.6 mu g/mL, SI = 11.1) used as a positive control against HRSV, while other extracts (M. conica methanol extract EC50 = 28055 mu g/mL, SI = >1.8; F. fomentarius methanol extract EC50 = 3000 mu g/mL, SI = 2.2) were found to have weak antiviral activity. As a result, it can be said that aqueous extract of F. fomentarius is worthy of further study as an alternative drugs in order to develop anti RSV.en10.13040/IJPSR.0975-8232.9(12).5240-45info:eu-repo/semantics/openAccessMorchella conicaFomes fomentariusMethanolic and aqueous extractsAntiviral activityRespiratory syncytial virusArticle91252405245#YOKWOS:000451885300025N/A