Asghari, BehvarZengin, GökhanBahadori, Mir BabakAbbas-Mohammadi, MahdiDinparast, Leila2020-03-262020-03-2620181876-38201876-3839https://dx.doi.org/10.1016/j.eujim.2018.08.004https://hdl.handle.net/20.500.12395/36307Introduction: Mint is used as a herbal tea, in food additives, and as a traditional medicine all around the world. They are popular functional foods and natural remedies. A comprehensive bioactivity evaluation was performed on wild mint essential oil to shed light on its health beneficial effects and therapeutic potential as a very popular herb. Methods: The chemical composition of essential oil of wild mint (Mentha longifolia var. calliantha (Stapf) Briq.) was determined together with its antioxidant and enzyme inhibitory potential linked to Alzheimer's disease, diabetes mellitus, and skin disorders. Six different methods were employed to examine antioxidant ability, including; DPPH, ABTS, CUPRAC, FRAP, metal chelating, and Molybdenum total antioxidant assays. Results: Findings showed that 1,8-cineol (33.5%), linalool (15.1%), menthone (12.9%), and trans-piperitone oxide (12.6%) are the main volatile compounds of the plant. The essential oil exhibited promising antiradical activity (5.8 and 9.1 mmol TEs/g oil in DPPH and ABTS assays, respectively) and reducing power (102 and 337 mmol TEs/g oil in FRAP and CUPRAC assays, respectively). Moreover, remarkable antidiabetic, anticholinesterase, and antityrosinase effects were recorded for the mint oil. Conclusion: Wild mint essential oil has valuable bioactive constituents and great potential for uses in food, pharmaceutical, and cosmeceuticals industries.en10.1016/j.eujim.2018.08.004info:eu-repo/semantics/closedAccessMentha longifolia1,8-cineolLinaloolAlzheimer's diseaseIntegrative medicineDiabetes mellitusArticle224449Q2WOS:000444917600006Q4