Corum, OrhanCorum, Duygu DurnaAltan, FerayEr, AyseCetin, GulUney, Kamil2020-03-262020-03-262019Corum, O., Corum, D. D., Altan, F., Er, A., Cetin, G., Uney, K. (2019). Pharmacokinetics Of İntravenous And İntramuscular Danofloxacin İn Red-Eared Slider Turtles (Trachemys Scripta Elegans). Journal Of Veterinary Medical Science, 81,(5), 753-757.0916-72501347-7439https://dx.doi.org/10.1292/jvms.18-0609https://hdl.handle.net/20.500.12395/38083This study aimed to investigate the pharmacokinetics of danofloxacin in red-eared slider turtle (Trachemys scripta elegans) following a single intravenous (IV) and intramuscular (IM) administrations of 6 mg/kg, using a two-way crossover study with 30-day washout period. Eight clinically healthy red-eared slider turtle weighing 410-600 g (mean 490 g) were used for the study. Danofloxacin concentrations were measured using the reversed-phase high-performance liquid chromatography. The plasma concentration-time data were evaluated by a non-compartmental method. After IV administration, the elimination half-life (t(1/2 lambda z)), mean residence time (MRT0-8), area under the concentration-time curve (AUC(0-infinity)), volume of distribution at steady state and total body clearance in plasma were 24.17 hr, 30.64 hr, 143.31 hr center dot mu g/ml, 1.29 l/kg and 0.04 l/hr/kg, respectively. Following IM administration, t1/2.z, MRT0-infinity, AUC(0-infinity), peak concentration (C-max), time to reach Cmax, and bioavailability in plasma were 32.00 hr, 41.15 hr, 198.23 hr center dot mu g/ml, 8.75 mu g/ml, 1.5 hr and 139.89%, respectively. Danofloxacin has clinically superior pharmacokinetic properties, including the complete IM absorption, slow elimination and wide volume of distribution in redeared slider turtles. However, further pharmacokinetics/pharmacodynamics studies are necessary for the treatment of diseases caused by susceptible bacteria with known minimum inhibitory concentration values in red-eared slider turtles.en10.1292/jvms.18-0609info:eu-repo/semantics/openAccessbioavailabilitydanofloxacinpharmacokineticsred-eared slider turtlesArticle81575375730853667Q2WOS:000472005900021Q3