Secci, DanielaCarradori, SimoneBizzarri, BrunaChimenti, PaolaDe Monte, CelesteMollica, AdrianoRivanera, Daniela2020-03-262020-03-2620160223-52341768-3254https://dx.doi.org/10.1016/j.ejmech.2016.04.012https://hdl.handle.net/20.500.12395/33835Pursuing our recent outcomes regarding the antifungal activity of N-substituted 1,3-thiazolidin-4-ones, we synthesized thirty-six new derivatives introducing aliphatic, cycloaliphatic and heteroaromatic moieties at N1-hydrazine connected with C2 position of the thiazolidinone nucleus and functionalizing the lactam nitrogen with differently substituted (NO2, NH2, Cl and F) benzyl groups. These compounds were tested to evaluate their minimum inhibitory concentration (MIC) against several clinical Candida spp. with respect to topical and systemic reference drugs (clotrimazole, fluconazole, ketoconazole, miconazole, tioconazole, amphotericin B). Moreover, anti-oxidant properties were also evaluated by using different protocols including free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum assays. Moreover, for the most active derivatives we assessed the toxicity (CC50) against Hep2 human cells in order to characterize them as multi-target agents for fungal infections. (C) 2016 Elsevier Masson SAS. All rights reserved.en10.1016/j.ejmech.2016.04.012info:eu-repo/semantics/openAccessAnti-Candida activityCytotoxicityN-benzyl-4-thiazolidinonesAnti-oxidant agentsMetal chelating agentsArticle11714415627100030WOS:000376837800012Q1