Acar, HasanStewart, JanetBoyd, ElizabethConnor, Michael J.2020-03-262020-03-261997Acar, H., Stewart, J., Boyd, E., Connor, M. J., (1997), Identification of Variant Translocations in Chronic Myeloid Leukemia by Fluorescence In Situ Hybridization. Cancer Genetics and Cytogenetics, 93(2), 115-118.0165-4608https://dx.doi.org/10.1016/S0165-4608(96)00168-9https://hdl.handle.net/20.500.12395/16585We studied two cases of chronic myeloid leukemia (CML) having variant complex translocations detected by trypsin G-banding and fluorescence in situ hybridization (FISH). Application of dual color- (DC-) FISH using abl and bcr cosmid probes permitted us to detect the bcr-abl fusion event on both interphase nuclei and metaphase spread. Furthermore, FISH using combinatorial hybridization (centromeric-library and library-library probes) demonstrated the content and the position of the translocations in CML patients with variant (complex type) Ph-positive rearrangements. FISH analysis appears to be superior than conventional cytogenetic analysis.en10.1016/S0165-4608(96)00168-9info:eu-repo/semantics/openAccessArticle9321151189078295N/AWOS:A1997WN73900002Q2