Kucukkolbasi, SemahatBilber, OnurAyyildiz, H. FilizKara, Huseyin2020-03-262020-03-2620130100-40421678-7064https://dx.doi.org/10.1590/S0100-40422013000700020https://hdl.handle.net/20.500.12395/29818In the present study, a reversed-phase high-performance liquid chromatographic (RP-HPLC) procedure was developed and validated for the simultaneous determination of seven water-soluble vitamins (thiamine, riboflavin, niacin, cyanocobalamin, ascorbic acid, folic acid, and p-aminobenzoic acid) and four fat-soluble vitamins (retinol acetate, cholecalciferol, alpha-tocopherol, and phytonadione) in multivitamin tablets. The linearity of the method was excellent (R-2 > 0.999) over the concentration range of 10-500 ng mL(-1). The statistical evaluation of the method was carried out by performing the intra-and inter-day precision. The accuracy of the method was tested by measuring the average recovery; values ranged between 87.4% and 98.5% and were acceptable quantitative results that corresponded with the label claims.en10.1590/S0100-40422013000700020info:eu-repo/semantics/openAccesssimultaneous determinationwater-soluble and fat-soluble vitaminsRP-HPLCArticle36710441051Q3WOS:000324596200021Q4