Guney, OCelik, JBArazi, MUstun, ME2020-03-262020-03-2620040967-58681532-2653https://dx.doi.org/10.1016/j.jocn.2003.10.019https://hdl.handle.net/20.500.12395/19035This study aims to evaluate the effects of gamma-hydroxybutyrate (GHB) after spinal cord trauma (SCT). Twenty rabbits were divided equally into four groups: group I was the sham-operated group, group 11 suffered from SCT but received no treatment, group III was given a dose of 400 mg/kg of GHB intravenously before SCT and group IV received the same dose after SCT. Cerebrospinal fluid (CSF) samples were obtained 30 min before SCT (T-0), at 60 (T-1) and 120 min (T-2) after SCT. There was a threefold increase in lactate levels from baseline value at T-2 in group 11, while statistically significant elevation of the lactate levels were not observed in groups III and IV. Glucose levels at T, and T2 were significantly lower in groups III and IV compared with the control group. The findings of this study demonstrate that GHB can control the increase of CSF lactate and glucose levels following SCT and that this metabolic effect may be associated with neuroprotective physiological changes. (C) 2004 Elsevier Ltd. All rights reserved.en10.1016/j.jocn.2003.10.019info:eu-repo/semantics/openAccessgamma-hydroxybutyratespinal cord traumacerebrospinal fluidArticle11551752015177397Q2WOS:000222378700016Q4