Çelik, J.Reisli, R.Tuncer, S.Duman, A.Ökeşli, S.2020-03-262020-03-262001Çelik, J., Reisli, R., Tuncer, S., Duman, A., Ökeşli, S., (2001). Prevention of Postoperative Nausea-Vomiting in Children: Comparison of Granisetron and Droperidol Plus Metoclopramide. Turk Anesteziyoloji ve Reanimasyon, 29(3), 135-139.1016-5150https://hdl.handle.net/20.500.12395/17660This study was performed to compare the efficacy of a droperidol-metoclopramide combination with granisetron to prevent postoperative nausea and vomiting after tonsillectomy with or without adenoidectomy in children. Ninety pediatric patients, ASA class I, aged 4-10 years, were enrolled in a prospective, randomized, double-blind investigation and assigned to one of two treatment regimens; granisetron 40 mg/kg (Group G, n=45), droperidol 50 mg/kg plus metoclopramide 0.25 mg/kg (Group DM, n=45). Antiemetic drugs were administered intravenaously (IV) after inhaled induction of general anaesthesia. The same standard general anesthetic technique was used. Tracheal extubation was performed while patients were still deeply anaesthetized. Acetaminophen (10-25 mg/kg PR) was applied for postoperative analgesia to all children. The rate of complete response, defined as no emesis and no need for rescue antiemetics, 0-3 h after anaesthesia were 85% in group G, 87% in group DM (p>0.05). No clinically important adverse events were observed in any of the groups.trinfo:eu-repo/semantics/closedAccessDroperidolGranisetronMetoclopramideNauseaPediatric anaesthesiaTonsillectomyVomitingArticle293135139N/A