Yuca, S. A.Cimbek, E. A.Sen, Y.Guevenc, O.Vatansev, H.Bugrul, F.Gun, F.2020-03-262020-03-2620170947-73491439-3646https://dx.doi.org/10.1055/s-0042-114220https://hdl.handle.net/20.500.12395/35605Objective: Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor-super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15.MIC-1/GDF15 is associated with cardio metabolic risk in adults. Design: Identification of obese children at higher risk for cardio metabolic complications is important. The relations of MIC-1/GDF15 to parameters of obesity in children have never been studied. Methods: We measured serum MIC-1/GDF15 concentration in obese children by ELSA and evaluated its relationship with anthropometric, biochemical and echocardiographic parameters. Results: No significant difference in serum MIC-1/GDF15 between normal-weight and obese children was observed. MIC-1/GDF15 was positively correlated with CRP, ALT and aortic dimension when normal-weight and obese children were analyzed together. Conclusions: MIC-1/GDF15 may provide a link between childhood obesity and cardio metabolic complications that will occur in time course. Further work would be required to find out if MIC-1/GDF15 has any role in the early inflammatory, cardiac and metabolic changes in childhood obesity.en10.1055/s-0042-114220info:eu-repo/semantics/closedAccessobesityMIC-1/GDF15inflammationcardiovascular risk managementArticle1252869027750354Q2WOS:000395508000003Q4