Oran, BülentTaştekin, AyhanKaraaslan, SevimBaş, LeventAyçiçek, AliÇeri, AyhanSütçü, AliErkul, İbrahim2020-03-262020-03-262000Oran, B., Taştekin, A., Karaaslan, S., Baş, L., Ayçiçek, A., Çeri, A., Sütçü, A., Erkul, İ., (2000). Prophylactic Efficiency of 3-Weekly Benzathine Penicillin G in Rheumatic Fever. Indian Journal of Pediatrics, 67(3), 163-167. Doi: 10.1007/BF027236520019-5456https://dx.doi.org/10.1007/BF02723652https://hdl.handle.net/20.500.12395/17316Benzathine penicillin G (BPG) is effective for secondary prophylaxis of rheumatic fever (RF). However, interval between injections a remains a controversial matter. In a study population of 74 patients, following the initial diagnosis of RF, 3-weekly BPG (1.2 million units) regimen was started. During the first three-week period, serum penicillin concentrations were examined on the 7th, 14th and 21st days and throat done for group-A b hemolytic streptococcal (GABHS) infection. Ten patients (13.5%) at 21st day of injection had low serum penicillin concentration after the first BPG. GABHS was isolated in 5 patients during this period. Although two of these 5 patients had symptoms of respiratory tract infection, according to laboratory data, the other three were accepted as carriers. There was no PR among regular (missing no more than one injection a year) group. We concluded that 3-weekly BPG regimen was satisfactory for secondary prophylaxis in RF, even though serum penicillin level was inadequate during the third week in some of the patients.en10.1007/BF02723652info:eu-repo/semantics/openAccessBenzathine penicillin G.Rheumatic feverSecondary prophylaxisArticle67316316710838716Q2