Demircan, EzgiEymur, SerkanDemir, Ayhan Sitki2020-03-262020-03-2620140957-4166https://dx.doi.org/10.1016/j.tetasy.2014.01.015https://hdl.handle.net/20.500.12395/31092A proline-calix[4]arene thiourea host-guest complex catalyzed intermolecular aldol reaction of aromatic aldehydes with cyclohexanone has been developed. The anti-configured products were obtained in good yields and with high enantioselectivities. The reaction is proposed to work via a modified Houk-List model, where the carboxylate part of the praline constitutes as a supramolecular system with the thiourea. The outcome of the study indicates the influence of the calix[4]arene thiourea on both the reactivity and selectivity in a non-polar reaction medium, even in the presence of water at moderate temperatures. (C) 2014 Elsevier Ltd. All rights reserved.en10.1016/j.tetasy.2014.01.015info:eu-repo/semantics/closedAccessArticle255443448N/AWOS:000334985000007Q2