Avci, AhmetDemir, KenanAltunkeser, Bulent BehlulYilmaz, SemaYilmaz, AhmetErsecgin, AhmetDemir, Tarik2020-03-262020-03-2620141082-720X1542-474Xhttps://dx.doi.org/10.1111/anec.12145https://hdl.handle.net/20.500.12395/30622Objectives: Systemic lupus erythematosus (SLE) is a chronic disease that affects many organ systems and manifests a broad spectrum of laboratory and clinical features. SLE patients have an increased risk of developing cardiovascular disease. The aim of this study was to evaluate inhomogeneities of repolarization by using T-peak-T-end (Tp-e) interval and Tp-e/QT ratio were measured from the 12-lead surface electrocardiogram (ECG) in patients with SLE. Material and method: This study included 69 SLE patients (69 females; mean age 35.8 +/- 10.2) and 57 control subjects (57 females; mean age 34.5 +/- 8.9). Transthoracic echocardiographic examination was done in all participants. QT parameters, Tp-e intervals and Tp-e/QT ratio were measured from the 12-lead ECG. These parameters were compared between groups. Results: No statistically significant difference was found between two groups in terms of basic characteristics. Diastolic function parameters were similar between the two groups (P > 0.05). In electrocardiographic parameters analysis, QT dispersion (QTd) and corrected QT dispersion (cQTd) were significantly increased in SLE patients compared the control group (49.5 +/- 16.4 ms vs. 32.8 +/- 11.7 ms and 56.7 +/- 19.5 ms vs. 36.4 +/- 13.1 ms, all P value < 0.001). Tp-e interval and Tp-e/QT ratio were also significantly higher in SLE patients (82.8 +/- 18.9 vs. 72.4 +/- 17.6 and 0.22 +/- 0.05 vs. 0.19 +/- 0.05, P = 0.002 and P = 0.001, respectively). Tp-e interval and Tp-e/QT were positively correlated with disease duration (r = 0.29, P = 0.01 and r = 0.24, P = 0.04, respectively). Conclusion: Our study revealed that QTd, cQTd, Tp-e interval and Tp-e/QT ratio increased in patients with SLE. Also, Tp-e interval and Tp-e/QT were positively correlated with disease duration.en10.1111/anec.12145info:eu-repo/semantics/closedAccesssystemic lupus erythematosusarrhythmiainhomogeneities of repolarizationTp-e intervalTp-e/QTArticle19437438224597863Q2WOS:000340092400011Q3