Çakır, MehtapCan, İlknur2020-03-262020-03-262006Çakır, M., Can, İ., (2006). Cardiovascular Abnormalities in Hyperthyroidism. American Journal of Medicine, 119(2), 187-188. Doi: 10.1016/j.amjmed.2005.08.0150002-9343https://dx.doi.org/10.1016/j.amjmed.2005.08.015https://hdl.handle.net/20.500.12395/20367Anthonisen et al in 1987 continues to be the landmark study. 3 The inclusion criteria required COPD with a FEV1 70% and FEV1/forced vital capacity 70%. It must be kept in mind that patients in the former study had a mean FEV1 of only 33.9% predicted. In another trial carried out in Italy, in which patients with a mean FEV1 of 35-40% predicted were included, clear and significant differences were observed between the antibiotic and placebo treatments.4 Moreover, in a new analysis of the same data, the authors demonstrated that patients with severe functional impairment are those who derive the greatest benefit from antibiotic therapy.en10.1016/j.amjmed.2005.08.015info:eu-repo/semantics/openAccessLetter119218718816443442Q1WOS:000234993900027Q1