Bahadori, Mir BabakDinparast, LeilaZengin, GökhanSarikurkcu, CengizBahadori, ShahramAsghari, BehvarMovahhedin, Nasrin2020-03-262020-03-2620171094-29121532-2386https://dx.doi.org/10.1080/10942912.2016.1218893https://hdl.handle.net/20.500.12395/35143Antidiabetic, anti-Alzheimer, general toxicity, and antioxidant activities of Salvia syriaca were evaluated. Phytochemical composition of the essential oil and methanolic extract of the plant were identified using gas chromatography-mass spectrometry and reverse-phase high-performance liquid chromatography-diode array detector techniques, respectively. Essential oil of S. syriaca exhibited strong cytotoxicity, antioxidant, a-amylase, and a-glucosidase inhibitory activities. Gas chromatography-mass spectrometry analysis showed that spathulenol (87.4%), isospathulenol (7.6%), and bornyl acetate (2.7%) are the major compounds in essential oil. High-performance liquid chromatography analysis indicated that rutin, quercetin, apigenin, rosmarinic acid, and ferulic acid are the most abundant phenolic components. S. syriaca could be considered as a valuable source of bioactive natural compounds for functional foods, medical, and pharmaceutical applications.en10.1080/10942912.2016.1218893info:eu-repo/semantics/openAccessSalvia syriacaAlzheimer'sdiseaseDiabetes mellitusPhenolic compoundsRutinSpathulenolArticle20817611772Q2WOS:000402969700007Q2