Atabek, MEPirgon, OKaragozoglu, E2020-03-262020-03-2620060019-6061https://hdl.handle.net/20.500.12395/20613Objective: Hyperhomocysteinemia has been established as a risk factor for cardiovascular disease. The objective was to investigate total plasma homocysteine concentrations in children. and adolescents with type 1 diabetes and a control group. Method: Twenty-seven children with type 1 diabetes and 27 subjects of an age- and sex-matched control group were recruited. Fasting samples were collected for plasma total homocysteine, serum vitamin B-12, folate, and creatinine. Results: Fasting total homocysteine concentrations showed no difference between patients and controls (5.6 +/- 2.9 mu mol/L vs 5.7 +/- 2.2 mu mol/L; p > 0.05). The diabetic patients had significantly higher serum folate than the healthy controls (11.4 +/- 3.3 ng/mL vs 9.4 +/- 4.1 ng/mL; P = 0.02 and higher serum B-12 than the control group (282.8 +/- 119 pg/mL vs 228.5 +/- 50.9 pg/mL; P = 0.03). Total plasma homocysteine concentration correlated with age (r = 0.44, P = 0.02), weight (r = 0.56, P = 0.002), body mass index (r = 0.57, P = 0.002), folate (r = -0.48, P = 0.01), and creatinine (r = 0.41, P = 0.03) in diabetic patients. In stepwise multivariate regression model for diabetics, the independent correlates for total plasma homocysteine concentration was folate (P = 0.002). Conclusion: We concluded that fasting plasma total homocysteine concentrations were within normal limits in children and adolescents with type 1 diabetes who were without any clinical evidence of microvascular and macrovascular complications.eninfo:eu-repo/semantics/closedAccessfolatehomocysteinetype 1 diabetesvitamin B-12Article43540140716735761Q2WOS:000237706600003N/A