Tuncer, SemaBarışkaner, HülagüYosunkaya, AlperTavlan, Aybars2020-03-262020-03-262002Tuncer, S., Barışkaner, H., Yosunkaya, A., Tavlan, A., (2002). Influence of Dexamethasone on Nausea and Vomiting During Patient-controlled Analgesia With Tramadol. Clinical Drug Investigation, 22(8), 547-552. Doi: 10.2165/00044011-200222080-000071173-25631179-1918https://dx.doi.org/10.2165/00044011-200222080-00007https://hdl.handle.net/20.500.12395/17975Objective: The aim of this study was to evaluate the prophylactic effect of dexamethasone on postoperative nausea and vomiting (PONV) during patient-controlled analgesia (PCA) with tramadol. Methods: 50 patients [American Society of Anesthesiologists (ASA) I-II] were enrolled in this randomised, placebo-controlled study. In group 1, saline was administered as a control. In group II, 150 mug/kg dexamethasone was administered as an intravenous bolus and then tramadol added in the PCA device. We assessed PONV and the need for rescue antiemetics in the 24 hours postoperatively. Results: 17 of 25 dexamethasone-treated patients (68%) had no nausea, four patients (16%) experienced nausea, two patients (8%) retched, two patients (8%) vomited once, no patients vomited repeatedly and seven patients (28%) required rescue antiemetics. In the placebo-treated group, three of 25 patients (12%) had no nausea, 12 (48%) had nausea, three (12%) retched, three patients (12%) vomited once, four patients (16%) vomited repeatedly and 17 patients (68%) required a rescue antiemetic, The incidence of nausea, vomiting and administration of a rescue antiemetic were significantly less in dexamethasone recipients compared with the saline-treated group (p < 0.05). There were no significant differences between the groups in the pain score results or in the consumption of tramadol. Conclusion: Our results demonstrate that a single dose of dexamethasone reduced the incidence of PONV during PCA with tramadol.en10.2165/00044011-200222080-00007info:eu-repo/semantics/openAccessArticle228547552Q2WOS:000177548400007Q3