Yilmaz, ElifSezgin, Mehmet2020-03-262020-03-2620120273-22891559-0291https://dx.doi.org/10.1007/s12010-012-9621-zhttps://hdl.handle.net/20.500.12395/28013Candida rugosa lipase was encapsulated within a chemically inert sol-gel support prepared by polycondensation with tetraethoxysilane and octyltriethoxysilane in the presence of beta-cyclodextrin-based polymer. The catalytic activity of the encapsulated lipases was evaluated both in the hydrolysis of p-nitrophenylpalmitate and the enantioselective hydrolysis of racemic Naproxen methyl ester. It has been observed that the percent activity yield of the encapsulated lipase was 65 U/g, which is 7.5 times higher than that of the covalently immobilized lipase. The beta-cyclodextrin-based encapsulated lipases had higher conversion and enantioselectivity compared with covalently immobilized lipase. The study confirms an excellent enantioselectivity (E > 300) for the encapsulated lipase with an enantiomeric excess value of 98% for S-naproxen.en10.1007/s12010-012-9621-zinfo:eu-repo/semantics/closedAccessCandida rugosa lipasebeta-cyclodextrinSol-gel encapsulationEnantioselective hydrolysisS-naproxenArticle16681927194022383051Q2WOS:000302771000004Q3