Zengin, GökhanLocatelli, MarcelloFerrante, ClaudioMenghini, LuigiOrlando, GiustinoBrunetti, LuigiRecinella, LuciaChiavaroli, AnnalisaLeone, SheilaLeporini, LidiaAumeeruddy, Muhammad ZakariyyahMahomoodally, Mohamad Fawzi2020-03-262020-03-262019Zengin, G., Locatelli, M., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Recinella, L., Chiavaroli, A., Leone, S., Leporini, L., Aumeeruddy, M. Z., Mahomoodally, M. F. (2019). New Pharmacological Targets Of Three Asphodeline Species Using İn Vitro And Ex Vivo Models Of İnflammation And Oxidative Stress. International Journal Of Environmental Health Research, 29,(5), 520-530.0960-31231369-1619https://dx.doi.org/10.1080/09603123.2018.1552930https://hdl.handle.net/20.500.12395/38032This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2O2)-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 gene expression in rat colon specimens. Interestingly, A. tenuior extract was most effective in improving the tested biomarkers, by reducing LDH activity and nitrite level. On the other hand, A. damascena was the only species able to blunt LPS-induced TNF-alpha gene expression in rat colon specimens. The present findings highlighted the protective effects of Asphodeline extracts via in vitro and ex vivo models of inflammation and oxidative stress, adding new insights to the pharmacological actions of these medicinal plant species.en10.1080/09603123.2018.1552930info:eu-repo/semantics/openAccessAsphodelineoxidative stressinflammationnatural agentspharmaceutical applicationsArticle29552053030514101Q2WOS:000477781000004Q3