Çorum, OrhanYıldız, Ramazanİder, MerveAltan, FerayOk, MahmutÜney, Kamil2020-03-262020-03-262019Corum, O., Yildiz, R., Ider, M., Altan, F., Ok, M., Uney, K. (2019). Pharmacokinetics and Bioavailability of Cefquinome and Ceftriaxone in Premature Calves. Journal of Veterinary Pharmacology and Therapeutics, 42(6), 632-639.0140-77831365-2885https://dx.doi.org/10.1111/jvp.12789https://hdl.handle.net/20.500.12395/38078The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome (CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) administrations in premature calves. Using a parallel design, 24 premature calves were randomly divided into the two antibiotic groups. Each of the six animals in the first group received CFQ (2 mg/kg) through IV or IM administration. The second group received CTX (20 mg/kg) via the same administration route. Plasma concentrations of the drugs were analyzed by high-performance liquid chromatography and noncompartmental methods. Mean pharmacokinetic parameters of CFQ and CTX following IV administration were as follows: elimination half-life (t(1/2 lambda z)) 1.85 and 3.31 hr, area under the plasma concentration-time curve (AUC(0-infinity)) 15.74 and 174 hr * mu g/ml, volume of distribution at steady-state 0.37 and 0.45 L/kg, and total body clearance 0.13 and 0.12 L hr(-1) kg(-1), respectively. Mean pharmacokinetic parameters of CFQ and CTX after IM injection were as follows: peak concentration 4.56 and 25.04 mu g/ml, time to reach peak concentration 1 and 1.5 hr, t(1/2 lambda z) 4.74 and 3.62 hr, and AUC(0-infinity) 22.75 and 147 hr * mu g/ml, respectively. The bioavailability of CFQ and CTX after IM injection was 141% and 79%, respectively. IM administration of CFQ (2 mg/kg) and CTX (20 mg/kg) can be recommended at 12-hr interval for treating infections caused by susceptible bacteria, with minimum inhibitory concentration values of <= 0.5 and <= 4 mu g/ml, respectively, in premature calves. However, further research is indicated to assess the pharmacokinetic parameters following multiple doses of the drug in premature calves.en10.1111/jvp.12789info:eu-repo/semantics/openAccessbioavailabilitycefquinomeceftriaxonepharmacokineticspremature calvesArticle42663263931197850Q2WOS:000501034000008Q2