Keskin, EDurgun, ZKocabatmaz, MTras, BEryavuz, ADonmez, N2020-03-262020-03-2619970269-8951https://hdl.handle.net/20.500.12395/16576We studied the effects of a cholesterol diet alone and of a cholesterol diet plus garlic oil on erythrocyte membrane phospholipid fractions in 10 adult mongrel dogs. The animals were fed the control diet plus 0.5% cholesterol for 6 weeks and the control diet containing 5% cholesterol plus garlic oil at 20 mg kg(-1) body weight daily for the last 3 weeks of the experiment. Feeding with the cholesterol-rich diet resulted in significant (p < 0.05) increases in erythrocyte membrane lipids. The administration of garlic oil not only prevented the increases but also reduced the levels of phospholipid and cholesterol, though not significantly. Although phospholipid (PL) fractions showed fluctuations with the cholesterol feeding and garlic oil administration, there was no significant difference between the sampling times. In conclusion, further studies are necessary on the effect of garlic on the membrane PL fractions because of the importance of PL in all aspects of membrane physiology from anion transport to regulation of cell structure.eninfo:eu-repo/semantics/closedAccesshypercholesterolaemiagarlic oilerythrocyte membranephospholipid fractionsArticle2511761763N/AWOS:A1997YH33500013Q4