Öztin, Öğün CemileTopal, AliDuman, AteşErol, A.Ökeşli, Selmin2020-03-262020-03-262002Öztin, Ö. C., Topal, A., Duman, A., Erol, A., Ökeşli, S., (2002). Remifentanil-sevoflurane-nitrous Oxide Anaesthesia: the Effects of Propofol or Thiopentone on Early Cognitive Function and Recovery in Moderate Aged and Elderly Women [remifentanil-sevofluran-azotprotoksit Anestezisinde Propofol ve Tiyopenton'un Orta ve ileri Yaştaki Kadinlarda Derlenmeye ve Erken Kognitif Fonksiyonlara Etkisi]. Türk Anesteziyoloji ve Reanimasyon, 30(5), 209-217.1016-5150https://hdl.handle.net/20.500.12395/18119In this study, we investigated the cognitive functions and recovery following thiopentone or propofol induction before remifentanil and sevoflurane-nitrous oxide anaesthesia, in patients undergoing total abdominal hysterectomy operations. In 67 ASA I-III class women (age:40-76), anaesthesia was induced with 1,5 mg/kg propofol in Group PR (n=31), and 5 mg/kg thiopentone in Group TR (n=36). Mivacurium was used for muscle relaxation. Anaesthesia was maintained with 0.25 ?/kg/h remifentanil, and a mixture of 0.5 MAC sevoflurane-nitrous oxide: oxygen (60:40). Heart rate (HR.), mean arterial pressure (MAP), respiratory rate (RR) and SpO2 were recorded. Mini-mental test (MMT), postanaesthesia Aldrete scoring (PAS) pain scores using visual analog scale (VAS) with the changing times of sedation scores using 4 point sedation scale were recorded simultaneousely. In group PR HR and MAP decreased after induction. In both groups MMT scores were lower than their preopertive values and MMT scores were decreased in group TR when compared to group PR postoperatively. (Preoperatively 23.1±3.7 vs 23.3±4.9, postoperatively 17.1±5.7 vs 14.0±6.0) (p<0.05). MMT application time was longer than Group PR. (p<O.05). In group TR, PAS scores were more decreased (Group TR: 7.2±1.3 and 9.0±0.9; Group PR: 8.3±1.3 and 9.6±0.5) (p<0.05). VAS scores were higher in Group TR. The incidence of postoperative nausea-vomiting was lower in Group PR (p<0.05). Thiopentone used for induction before nitrousoxide-remifentanil-sevoflurane anaesthesia considerably prolonged the return of early cognitive functions and recovery time in middle-advanced aged women when compared with propofol.trinfo:eu-repo/semantics/closedAccessAgeCognitive functionPropofolRemifentanilSevofluranThiopentoneArticle305209217N/A