Genc, E.Avunduk, M. C.Genc, B. OguzSahin, A. SaideOz, M.2020-03-262020-03-2620090001-6314https://dx.doi.org/10.1111/j.1600-0404.2008.01153.xhttps://hdl.handle.net/20.500.12395/23934Objective - To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods - Male Sprague-Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test. Results - A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain. Conclusion - Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.en10.1111/j.1600-0404.2008.01153.xinfo:eu-repo/semantics/closedAccessdipyroneimmunohistochemical stainingratserotonin expressionsumatriptanArticle120426426919432933Q2WOS:000269861800009Q2