Kaplan, HüseyinCengiz, GizemŞaş, SenemKara, Hasan2024-03-182024-03-182024 ŞubatKaplan, H., Cengiz, G., Şaş, S., Kara, H., (2024). Examining the Seroprevalance and Antiviral Prophylaxis Rate of Hepatitis B and C Virus in Rheumatic Patients Treated with Biological and Targeted Synthetic Disease Modifying Anti-rheumatic Drugs: Results from a Tertiary Center in Central Anatolia. Genel Tıp Dergisi, 34(1), 88-93. DOI: 10.54005/geneltip.13623072602-3741https://hdl.handle.net/20.500.12395/52470ABSTRACT Objective: To evaluate the epidemiological characteristics of hepatitis B virus (HBV) and hepatitis C virus (HCV) in rheumatic patients treated with biological and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs). Methods: This cross-sectional study was carried out between September 2021 and April 2022 at the Rheumatology Outpatient Clinic of Erciyes University Faculty of Medicine, and it included 200 patients [113 with axial spondyloarthritis (axSpA), 18 with psoriatic arthritis (PsA) and 69 with rheumatoid arthritis (RA)]. The demographic and clinical characteristics, treatment details and viral hepatitis serology of the patients were recorded. Those not receiving biological and/or targeted synthetic DMARDs (b/tsDMARDs) were excluded. Results: The median age of the patients was 47 (39-58) years, and the median disease duration was 10 (7-15) years. Of the patients, 117 (58.5%) were female and 83 (41.5%) were male. The median duration of treatment with b/tsDMARDs was 6 (2-9) years. In the viral serological examinations, 1.5% of the patients were positive for HBsAg, 64.5% for anti-HBs, 23.5% for anti-HBc IgG, and 0.5% for anti-HCV. The anti-HBc IgG positivity rate was significantly higher in RA (34.8%) than axSpA patients (16.8%) and was similar to PsA patients (22.2%) (p = 0.023). Yet HBsAg, anti-HBs, and antiHCV serologies were similar across patient subgroups (p > 0.05). A total of 44 (22%) patients were undergoing oral antiviral prophylaxis. Three (1.5%) patients who were anti-HBc positive and HBV DNA negative were followed without antiviral treatment. There was no viral reactivation in any patient. Conclusion: Approximately one in four patients in our cohort showed anti-Hbc positivity, and almost all of them were using antiviral prophylaxis. Anti-HCV prevalence was much lower. Studies addressing viral hepatitis in rheumatic patients and/or patient subgroups, both at the national and local level, will enable rheumatologists to be more effective in managing HBV and HCV.ÖZ Amaç: Biyolojik ve hedefe yönelik sentetik hastalık modifiye edici antiromatizmal ilaçlar (DMARD) ile tedavi edilen romatizmal hastalarda hepatit B virüsü (HBV) ve hepatit C virüsü (HCV)’nün epidemiyolojik özelliklerini değerlendirmek. Gereç ve Yöntem: Bu kesitsel çalışma Eylül 2021 ile Nisan 2022 tarihleri arasında Erciyes Üniversitesi Tıp Fakültesi Romatoloji Polikliniği’nde gerçekleştirildi ve 200 hasta [113’ü aksiyal spondiloartrit (akSpA), 18’i psöriyatik artrit (PsA) ve 69’u romatoid artrit (RA)]) dahil edildi. Hastaların demografik ve klinik özellikleri, tedavi detayları ve viral hepatit serolojileri kaydedildi. Biyolojik ve/veya hedefe yönelik sentetik DMARD (b/tsDMARD) almayanlar çalışmadan dışlandı. Bulgular: Hastaların medyan yaşı 47 (39-58) yıl, medyan hastalık süresi ise 10 (7-15) yıldı. 117’si (%58,5) kadın, 83’ü (%41,5) erkekti. B/tsDMARD ile medyan tedavi süresi 6 (2-9) yıldı. Viral serolojik incelemelerde hastaların %1,5’inde HBsAg, %64,5’inde anti-HBs, %23,5’inde anti-HBc IgG ve %0,5’inde anti-HCV pozitifliği tespit edildi. Anti-HBc IgG pozitifliği oranı RA hastalarında (%34,8) axSpA hastalarına (%16,8) göre anlamlı derecede yüksekti ve PsA hastalarına (%22,2) benzerdi (p = 0,023). Ancak HBsAg, anti-HBs ve anti-HCV serolojileri hasta alt grupları arasında benzerdi (p > 0,05). Toplam 44 (%22) hasta oral antiviral profilaksi tedavisi altındaydı. Anti-HBc pozitif ve HBV DNA negatif olan 3 (%1,5) hasta antiviral tedavi uygulanmadan takip edildi. Hiçbir hastada viral reaktivasyon görülmedi. Sonuç: Kohortumuzdaki yaklaşık dört hastadan biri anti-Hbc pozitifliği gösterdi ve neredeyse tamamı antiviral profilaksi kullanıyordu. Anti-HCV prevalansı çok daha düşüktü. Romatizmal hastalarda ve/ veya hasta alt gruplarında viral hepatitleri ele alan hem ulusal hem de yerel düzeydeki çalışmalar, romatologların HBV ve HCV’yi yönetmede daha etkin olmalarını sağlayacaktır.en10.54005/geneltip.1362307info:eu-repo/semantics/openAccessAxial spondyloarthritisHBVHCVPsoriatic arthritisRheumatoid arthritisAksiyal spondiloartritpsöriyatik artritromatoid artritArticle3418893