Sahin, MustafaKorkmaz, HaticeKocak, NuriyeSahin, OzlemKarakurt, SerdarYilmaz, Mustafa2020-03-262020-03-2620171060-13251520-5738https://dx.doi.org/10.1080/10601325.2017.1294451https://hdl.handle.net/20.500.12395/35508The metal complexes of Zn(II), Ni(II), Cu(II) and Pb(II) with asymmetrical Schiff bases were synthesized. The asymmetrical Schiff base was obtained through the condensation of 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde and biphenyl-4-carbaldehyde. The new Schiff base ligands (L-1' and L-2') and their metal complexes were characterized by TG/DTG, FT-IR, H-1-NMR, UV-Vis, ESR, powder XRD, elemental analysis, magnetic moment and fluorescence studies. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, while Ni(II) and Zn(II) complexes are crystalline. The anticarcinogenic effects of L-1' and L-2' were also investigated against colon (SW-620) and cervical cancer (HeLa) cell lines and compound L-2' was found to possess the highest anticarcinogenic potential, with 16.7 mu M and 27.5 mu M of IC50 values for HeLa and SW620 cells, respectively.en10.1080/10601325.2017.1294451info:eu-repo/semantics/closedAccessAnticancer activityESRmetal complexesSchiff baseXRDArticle545288300Q2WOS:000399809000003Q3