Erdemir, Serkan.Malkondu, Sait.2020-03-262020-03-262020Erdemir, S., Malkondu, S. (2020). Calix[4]arene Based a NIR-fluorescent Sensor with an Enhanced Stokes Shift for the Real-time Visualization of Zn(II) in Living Cells. Sensors and Actuators B: Chemical, 306, 1-8.0925-4005https://dx.doi.org/10.1016/j.snb.2019.127574https://hdl.handle.net/20.500.12395/38515Zinc(II) plays key roles actively involved in fundamental biological functions in the body. However, zinc dysmetabolism results in a number of human diseases. Therefore, miscellaneous techniques are needed to understand the complete biological role of Zn(II) in tissues and cells. Here, we introduce a novel calix[4]arene derivative (CIP), appended with two isophorone units via a 4-bromophenol linker for the fluorescence sensing Zn (II). CIP showed high fluorogenic selectivity for Zn(II) over a wide range of biologically and environmentally relevant metal ions in DMSO/H2O (v/v, 8/2, PBS buffer, 0.5 mM, pH 7.4) and has superior sensitivity of (6.75 nM) for Zn(II). Free CIP has very low emission but demonstrated the distinct "turn-on" emission enhancement response toward Zn(II) at near infrared region. CIP allowed the fabrication of a rapid and convenient TLC strip sensor for Zn(II)-selective detection. Moreover, this is the first report on a calix[4]are derivative used as a NIR fluorescence probe that monitors changes in intracellular Zn(II) levels and can penetrate into living cells.en10.1016/j.snb.2019.127574info:eu-repo/semantics/openAccessNIRFluorescenceSensorBioimagingZincArticle30618Q1WOS:000507459500008Q1