Öztekin, E.Moğulkoç, R.Baltacı, A. K.Tiftik, A. M.2020-03-262020-03-262005Öztekin, E., Moğulkoç, R., Baltacı, A. K., Tiftik, A. M., (2005). The Effect of Estradiol and Progesterone Application on Leptin Concentration in Ovariectomized Rats. Acta Physiologica Hungarica, 92(1), 27-31.0231-424Xhttps://dx.doi.org/10.1556/APhysiol.92.2005.1.4https://hdl.handle.net/20.500.12395/20046The aim of the present study was to investigate the effects of estradiol and progesterone application on leptin secretion in ovariectomised rats. The study included 30 adult female Sprague-Dawley rats. Rats were divided into three groups as follows:Group 1; Sham ovariectomy group (n=10), Group 2; Ovariectomy group (n=10), Group 3; Ovariectomized and estradiol propionate (450 ?g/kg rat) and medroxyprogesterone acetate (15 mg/kg rat) supplemented group (n=10). One week after ovariectomy, rats in Group 3 were injected estradiol and progesterone for 4 weeks. Twenty-four hours after the last injection, rats were decapitated and blood samples were collected for leptin analysis. Serum leptin levels in Group 2 were found significantly higher than those in Groups 1 and 3 (p<0.01), while those in Group 3 were significantly lower when compared to Group 1 (p<0.01). The findings of the present study have shown that ovariectomy led to a significant increase in leptin levels. However, administration of estradiol and progesterone in combination following ovariectomy inhibites increases of leptin levels.en10.1556/APhysiol.92.2005.1.4info:eu-repo/semantics/openAccessEstradiol applicationLeptinOvariectomyProgesterone applicationRatArticle921273116003942N/A