Kocabeyoglu, SibelMocan, Mehmet CemIrkec, MuratPinar, AsliBozkurt, BanuOrhan, Mehmet2020-03-262020-03-2620131120-67211724-6016https://dx.doi.org/10.5301/ejo.5000246https://hdl.handle.net/20.500.12395/29809Purpose: To determine the association of serum vitamin D levels with exfoliation syndrome (XFS) and evaluate its impact on co-associated systemic diseases. Methods: Forty patients with XFS and 40 control subjects without XFS were recruited for this study Serum concentrations of 25-hydroxy vitamin D [25(OH) D] were measured by high-performance liquid chromatography Vitamin D deficiency was defined as a serum 25(OH) D concentration of <20 ng/mL. A detailed medical history including hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular stroke, autoimmune disease, and neurologic disorders such as Parkinson disease and Alzheimer disease was recorded. Student t test and chi-square test was used for statistical evaluations. Results: The mean age of patients with XFS and control subjects was 69.6 +/- 8.1 years (range 58-90 years) and 67.1 +/- 6.3 years (range 60-86 years), respectively (p>0.05). Mean 25(OH) D levels did not differ between XFS (19.8 +/- 8.3 ng/mL) and control (19.9 +/- 10.3 ng/mL) groups (p = 0.978). Patients with XFS had higher prevalence of cerebrovascular (p = 0.026) and cardiovascular disease (p = 0.001). There was no association between the systemic disease status and serum vitamin D levels of patients with XFS. Conclusions: Although vitamin D levels were similar between XFS and control subjects, the levels were found to be decreased in both groups. Patients with XFS had a significantly higher prevalence of cerebrovascular and cardiovascular disease as compared to controls independent of their serum 25(OH) D levels. Low vitamin D level does not appear to be linked to XFS in the studied population.en10.5301/ejo.5000246info:eu-repo/semantics/closedAccessCardiovascular diseaseCerebrovascular diseaseExfoliation syndromeVitamin DArticle23452653123564611Q2WOS:000324152400010Q4