Ozyilmaz, ElifSayin, Serkan2020-03-262020-03-2620131615-75911615-7605https://dx.doi.org/10.1007/s00449-013-0941-3https://hdl.handle.net/20.500.12395/29156Candida rugosa lipase (CRL) was encapsulated via the sol-gel method, using 5, 11, 17, 23-tetra-tert-butyl-25,27-bis(2-aminopyridine)carbonylmethoxy-26, 28-dihydroxy-calix[4]arene-grafted magnetic Fe3O4 nanoparticles (Calix-M-E). The catalytic activity of encapsulated lipase (Calix-M-E) was tested both in the hydrolysis of p-nitrophenyl palmitate (p-NPP) and the enantioselective hydrolysis of racemic naproxen methyl ester. The present study demonstrated that the calixarene-based compound has the potential to enhance both reaction rate and enantioselectivity of the lipase-catalyzed hydrolysis of racemic naproxen methyl ester. The encapsulated lipase (Calix-M-E) had great catalytic activity and enantioselectivity (E > 400), as well as remarkable reusability as compared to the encapsulated lipase without supports (E = 137) for S-Naproxen.en10.1007/s00449-013-0941-3info:eu-repo/semantics/closedAccessNanoparticlesFe3O4LipaseCalixareneEnantioselectivityArticle36111803180623525833Q2WOS:000325772600028Q2