Baltacı, Abdülkerim KasımBediz, Cem ŞerefMoğulkoç, RasimKurtoğlu, ErdalPekel, Aysel2020-03-262020-03-262003Baltacı, A. K., Bediz, C. Ş., Moğulkoç, R., Kurtoğlu, E., Pekel, A., (2003). Effect of Zinc and Melatonin Supplementation on Cellular Immunity in Rats With Toxoplasmosis. Biological Trace Element Research, (96), 237-245. Doi: 10.1385/BTER:96:1-3:2370163-4984https://dx.doi.org/10.1385/BTER:96:1-3:237https://hdl.handle.net/20.500.12395/18437The effects of zinc (Zn) and/or melatonin supplementation on cellular immunity were investigated in rats infested with Toxoplasma gondii. Fifty Sprague-Dawley male rats were used for this study. All animals were fed a normal diet, ad libitum, containing 97 mg Zn/kg. They were divided into five experimental groups, as follows. Group I (n = 10) received intraperitoneal injections of zinc sulfate at a dose of 3 mg/kg/d for 3 wk. Group II (n = 10) received intraperitoneal injections of melatonin at a dose of 3 mg/kg/d for 3 wk. Group III (n = 10) received intraperitoneal injections of zinc sulfate (3 mg/kg/d) and melatonin (3 mg/kg/d) for 3 wk. Group IV (n = 10) was infested controls. Group V (n = 10) was healthy controls. There were no differences in the percentage of CD3+ lymphocytes among all groups. For groups I-III, the CD4+ and CD8+ ratios were higher than those of the groups IV and V controls (p < 0.01). Similarly, the total lymphocyte ratios in groups I-III were higher than those of infested and healthy controls (p < 0.01). The total lymphocyte ratios in group III were significantly higher than those of groups I and 11 (p < 0.01). The plasma Zn levels in the supplemented groups were significantly higher than those of control groups IV and V (p < 0.01). These results suggest that melatonin and/or Zn supplementation may activate cellular immunity by stimulating CD4+ and CD8+ production in infected rats with T. gondii.en10.1385/BTER:96:1-3:237info:eu-repo/semantics/openAccessCellular İmmunityMelatoninToxoplasmosisToxoplasma GondiiZinc SupplementationArticle9623724514716103Q1WOS:000187916600022Q4