L-proline derivatives based on a calix[4]arene scaffold as chiral organocatalysts for the direct asymmetric aldol reaction in water

Aktaş, MehmetUyanık, ArzuEymur, SerkanYılmaz, Mustafa2020-03-262020-03-2620161061-02781029-0478https://dx.doi.org/10.1080/10610278.2015.1073288https://hdl.handle.net/20.500.12395/33763A new series of water-compatible proline catalysts (4-6) derived from calixarene bearing a hydrophobic nature have been synthesised. It was found that the compound 4 was a highly efficient organocatalyst for aldol reactions occurred in the water. Under optimised reaction conditions, high yields (up to 82%), good enantioselectivities (ee up to 81%) and high diastereoselectivities (dr up to 91:9) were obtained.en10.1080/10610278.2015.1073288info:eu-repo/semantics/closedAccessCalix[4]areneorganocatalysisenantioselectivealdolL-proline derivatives based on a calix[4]arene scaffold as chiral organocatalysts for the direct asymmetric aldol reaction in waterArticle2805.06.2020351359Q3WOS:000373283800004Q3