Baltaci, Saltuk BugraMogulkoc, RasimBaltaci, Abdulkerim Kasim2020-03-262020-03-262019Baltaci, S. B., Mogulkoc, R., Baltaci, A. K. (2019). Molecular Mechanisms Of Early And Late LTP. Neurochemical Research, 44,(2), 281-296.0364-31901573-6903https://dx.doi.org/10.1007/s11064-018-2695-4https://hdl.handle.net/20.500.12395/38008LTP is the most intensively studied cellular model of the memory and generally divided at least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates biochemical events and trafficking of proteins, which eventually potentiate synaptic transmission, and is independent of de novo protein synthesis. In contrast, L-LTP requires gene expression and local protein synthesis regulated via TrkB receptor- and functional prions CPEB2-3-mediated translation. Maintenance of LTP for longer periods depends on constitutively active PKM. Throughout this review, current knowledge about early and late phases of LTP will be reviewed.en10.1007/s11064-018-2695-4info:eu-repo/semantics/openAccessLtpFunctional prionsCpebPkm zetaSynaptic plasticityLearning and memoryReview44228129630523578Q1WOS:000458993300001Q3