Genç, Bülent OğuzDoğan, Ebru ApaydınDoğan, UmuttanGenç, Emine2020-03-262020-03-262010Genç, B. O., Doğan, E. A., Doğan, U., Genç, E., (2010). Anthropometric Indexes, Insulin Resistance, and Serum Leptin and Lipid Levels in Women With Cryptogenic Epilepsy Receiving Topiramate Treatment. Journal of Clinical Neuroscience, (17), 1256-1259. Doi: 10.1016/j.jocn.2010.01.0450967-58681532-2653https://dx.doi.org/10.1016/j.jocn.2010.01.045https://hdl.handle.net/20.500.12395/24620We aimed to investigate the effects of topiramate monotherapy on anthropometric indexes, insulin resistance, and serum leptin and lipid levels in 33 premenopausal women (mean age +/- standard deviation: 26.7 +/- 7.1 years) with cryptogenic epilepsy. Body mass index (BMI), waist circumference and serum leptin, insulin and lipid levels were measured at baseline and at 6 months after initiation of topiramate. We found reductions in BMI (p < 0.001), waist circumference (p < 0.001) and serum high-density lipoprotein (HDL) cholesterol levels (p = 0.011). We also found significant improvements in insulin resistance (p = 0.023), but not in serum leptin levels (p = 0.45). Our results suggest that topiramate treatment in women with epilepsy is associated with reduced BMI and waist circumference and improvement in insulin resistance; however, according to our data, topiramate treatment is also associated with lower HDL cholesterol levels, which may substantially increase vascular disease.en10.1016/j.jocn.2010.01.045info:eu-repo/semantics/openAccessBody mass indexHDL cholesterolInsulin resistanceLeptin topiramateWaist circumferenceArticle171256125920598547Q2WOS:000281499900007Q4