Mogulkoc, RBaltaci, AKOztekin, EOzturk, ASivrikaya, A2020-03-262020-03-2620050236-5383https://dx.doi.org/10.1556/ABiol.56.2005.3-4.6https://hdl.handle.net/20.500.12395/19873Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.en10.1556/ABiol.56.2005.3-4.6info:eu-repo/semantics/openAccesshypothyroidismthyroxine administrationoxidant stressratArticle5603.04.202022523216196198N/AWOS:000231917900006Q4