Turan, HaleŞerefhanoğlu, KıvançApilioğulları, BurhanArıbaş, Olgun KadirEkici, ZuhalTimurkaynak, FundaArslan, Hande2020-03-262020-03-2620141302-78081308-5387http://www.trdizin.gov.tr/publication/paper/detail/TVRjd09EZ3pNdz09https://hdl.handle.net/20.500.12395/30473Kikuchi-Fujimoto disease is a benign self-limited syndrome with distinct histopathologic characteristics. Clinical symptoms include cervical lymphadenopathy with tenderness, fever of medium grade, night sweats, nausea, vomiting, and a sore throat. It is a rare disease worldwide. Diagnosis is based on histopathologic fndings from an excisional lymph node biopsy. We present the case of a 37-year-old male patient with a fever of 15 days duration. Clinical examination revealed no other pathologic signs except for oral aphthous lesions and a fever of unknown origin. The patients fever did not resolve after 15 days follow-up, and the results of computed tomographic study of the thorax revealed several sites of mediastinal lymphadenopathy. The diagnosis of Kikuchi-Fujimoto disease (histiocytic necrotising lymphadenitis) was based on the results of pathologic examination of the biopsy specimen. The patients signs and symptoms resolved without antibiotic therapy. This case report of a patient with a fever of unknown origin is presented because of the rare involvement of mediastinal lymphadenopathy without cervical lymphadenopathy. Kikuchi-Fujimoto disease should be considered in the differential diagnosis of the patient who presents with fever and mediastinal lymphadenopathy.eninfo:eu-repo/semantics/openAccessKulakBurunBoğazSolunum SistemiArticle1526567