Erdemir, SerkanSahin, OzlemUyanik, ArzuYilmaz, Mustafa2020-03-262020-03-2620091388-31271573-1111https://dx.doi.org/10.1007/s10847-009-9562-5https://hdl.handle.net/20.500.12395/23463Synthesis of the glutaraldehyde derivatives calix[n]arene (n = 4,6,8) (Calix[n]-GA) and using as cross-linkers for immobilization of Candida rugosa lipase (CRL) have been discussed in this paper. The amino functional calix[n]arene derivatives (Calix[n]-NH (2)) were synthesized via reduction of dinitrile, hexanitrile and octanitrile derivatives of calix[n]arenes. These amino functional calix[n]arene derivatives (Calix[n]-NH (2)) were converted to their aldehyde derivativatives with glutaraldehyde. The calix[n]arene derivatives were used in lipase immobilization in order to see the role of calix[n]arene binding site on the lipase activitiy and stability. The activity recovery of calix[n]arene-supported lipases (Calix[n]-CRL) based on the Calix[4]-CRL, Calix[6]-CRL and Calix[8]-CRL reaches to 53.5, 66.1 and 76.4%, respectively.en10.1007/s10847-009-9562-5info:eu-repo/semantics/closedAccessCalixareneCross-linkerImmobilizationCandida rugosa lipaseGlutaraldehydeArticle6403.04.2020273282Q3WOS:000267662800009Q3