Eryılmaz, M. A.İğci, A.Müslümanoğlu, M.Özmen, V.Koç, M.2020-03-262020-03-262012Eryilmaz, M. A., Igci, A., Muslumanoglu, M., Ozmen, V. Koc, M., (2012). Male Breast Cancer: A Retrospective Study of 15 Years. Journal of Buon, 17(1), 51-56.1107-06252241-6293https://hdl.handle.net/20.500.12395/28208Purpose: To retrospectively evaluate the 15-year experience with breast cancer in males at a single institution. Methods: The data from 25 male patients who had undergone surgery for breast cancer at a single center were retrospectively analysed. Their medical records were studied for clinical characteristics, therapeutic modalities used and factors associated with disease free (DFS) and overall survival (OS), like local recurrence/distant metastasis. Results: The median patient age was 67 years (range 38-83). The most frequent presenting symptom was a palpable lump. Eighteen (72%) patients underwent modified radical mastectomy (MRM), while sentinel lymph node biopsy (SLNB) was performed in 14(56%) cases. Of 25 patients, 21 (84%) underwent axillary lymph node dissection (ALND) and 15(71.4%) of them had pathological axillary lymph node involvement. Two of 25 (8%) patients with bone and liver metastases underwent toilet mastectomy due to breast ulceration. Estrogen receptor (ER) was positive in 15 (60%) patients, while progesterone receptor (PR) and C-erbB2 (HER-2) were positive in 10 (40%) and 2 (8%) patients, respectively Ten patients (40%) had both ER(+) and PR(+). The median follow-up period was 19 months (range 3-102). Local recurrence developed in one (4%) patient and distant metastasis in 4(16%). Five-year OS and DFS were 53 and 49%, respectively. In univariate and multivariate analysis, pathological tumor size (<2 vs. >2 cm), pathological lymph node involvement and preoperative skin involvement over the breast were not associated with breast recurrence. Only in univariate analysis local recurrence/distant metastasis were associated with poor OS. Conclusion: Large cooperative studies are needed using strict clinical and laboratory criteria to advance the understanding of this disease and to identify the most effective treatment approaches.eninfo:eu-repo/semantics/closedAccessmale breast cancersentinel lymph node biopsytissue-sparing surgeryArticle171515622517693Q3WOS:000302503700008Q4