Salbacak, A.Çelik, I.Karabulut, A. K.Özkan, Y.Uysal, I. I.Çiçekçibaşı, A. E.2020-03-262020-03-262001Salbacak, A., Çelik, I., Karabulut, A. K., Özkan, Y., Uysal, I. I., Çiçekçibaşı, A. E., (2001). Effects of Morphine on the Rat Lymphoid Organs and Adrenal Glands: Results of Enzyme Histochemical and Histometric Investigations. Revue De Medecine Veterinaire, 152(10), 691-698.0035-1555https://hdl.handle.net/20.500.12395/17539Effects of morphine on the rat lymphoid tissues and adrenal glands were investigated by means of histological, histometrical and enzyme histochemical methods. The experimental animals were treated with 5 mg/kg morphine hydrochloride at daily intervals for 30 days. Morphine treatment caused severe lymphoid cell depletion from spleen, thymus and lymph nodes whereas, ileal Peyer's patches were affected moderately. Both peripheral blood lymphocyte percentage and ANAE-positive lymphocyte frequency in the lymphocyte fraction decreased. The changes in lymphoid organs provide morphological evidence for morphine induced immune suppression. Along with these, observation of the thickening of the adrenal cortex and medulla might show that morphine induced immuno suppression may occur via increased glucocorticoid secretion.eninfo:eu-repo/semantics/closedAccessMorphineRatLymphoid OrgansAdrenal GlandsArticle15210691698Q3WOS:000172514700003Q4