Eren, FettahAygül, RecepÖztürk, Şerefnur2020-03-262020-03-262019Eren, F., Aygül, R., Öztürk, Ş. (2019). Pulmonary Adenocarcinoma Presented With Lambert Eaton Myasthenic Syndrome. Eastern Journal of Medicine, 24(3), 386-389.1301-08831339-3886https://dx.doi.org/10.5505/ejm.2019.58855http://www.trdizin.gov.tr/publication/paper/detail/TXpJM01Ea3hNUT09https://hdl.handle.net/20.500.12395/37332Paraneoplastic neurological syndrome is an autoimmune disease caused by distant effect of tumor. Lambert - Eatonmyasthenic syndrome (LEMS) is a paraneoplastic disease that is associated with voltage-dependent calcium channelantibodies. These autoantibodies affect especially presynaptic neuromuscular area. A 65 -year-old male patient admitted tohospital with complaint of dizziness, walking difficulty, and difficulty in getting up stairs. Neur ological examinationshowed mild muscle weakness proximal of lower extremities. Deep tendon reflexes were hypoactive. Sensory nerveconduction was normal in the electroneuromyography. All motor nerve compound muscle action potential (CMAP)amplitudes were decreased. After 10 seconds of exercise, amplitude increased more than 100%. More than 10% decrementwas observed at low frequencies in ulnar repetitive nerve stimulation. More than 200% increment was observed with 50 Hztetanic stimulation. Lung adenocarcinoma was diagnosed with thorax computerized tomography and bronchoscopicbiopsy. In the electrophysiological analyses of LEMS, significant amplitude increment is diagnostic with high frequencytetanic stimulation. Increment following short-term exercise is an easier alternative method to tetanic stimulation.en10.5505/ejm.2019.58855info:eu-repo/semantics/openAccessDiş HekimliğiFarmakoloji ve EczacılıkToksikolojiArticle243386389Q4