Naziroglu, Hayriye NevinDurmaz, MustafaBozkurt, SelahattinSirit, Abdulkadir2020-03-262020-03-2620110899-00421520-636Xhttps://dx.doi.org/10.1002/chir.20948https://hdl.handle.net/20.500.12395/26160Four proline-derived chiral receptors 5-8 were readily synthesized starting from L-proline. The enantiomeric recognition ability of chiral receptors was examined with a series of carboxylic acids by H-1 NMR spectroscopy. The molar ratio and the association constants of the chiral compounds with each of the enantiomers of guest molecules were determined by using Job plots and a nonlinear least-squares fitting method, respectively. The Job plots indicate that the hosts form 1:1 instantaneous complexes with all guests. The receptors exhibited different chiral recognition abilities toward the enantiomers of racemic guests. Among the chiral receptors used in this study, prolinamide 6 was found to be the best chiral shift reagent and is effective for the determination of the enantiomeric excess of chiral carboxylic acids. Chirality 23:463-471, 2011. (C) 2011 Wiley-Liss, Inc.en10.1002/chir.20948info:eu-repo/semantics/closedAccesschiral recognitionL-prolinecarboxylic acidNMR titrationenantiomeric excessArticle23646347121472784Q3WOS:000292038800004Q2