Vatansev, CelalettinÜstün, M. E.Öğün, C. O.Taştekin, G.Karabacakoğlu, A.Yılmaz, H.2020-03-262020-03-262003Vatansev, C., Üstün, M. E., Öğün, C. O., Taştekin, G., Karabacakoğlu, A., Yılmaz, H., (2003). Omental Transposition Decreases Ischemic Brain Damage Examined in a New Ischemia Model. European Surgical Research, (35), 388-394. Doi: 10.1159/0000706120014-312Xhttps://dx.doi.org/10.1159/000070612https://hdl.handle.net/20.500.12395/18518Purpose:The aim of this study was to determine whether omental transposition at the time of focal cerebral ischemia can decrease ischemic brain damage produced in dogs, in a new ischemia model, which had been described by us. Methods: In group 1 (n = 5), the left internal carotid artery and arterial circle of the brain (posterior communicating artery in humans) were occluded permanently. In group 2 (n = 5), additionally to this ischemia model, omental transposition was performed simultaneously. In the postoperative early period (first 24 h), single photon emission computed tomography (SPECT) and in the late period (72-96 h) SPECT and magnetic resonance imaging (MRI) of the brain were performed. Mann-Whitney U, paired t and Wilcoxon signed rank tests were used for statistical analyses, and p < 0.05 was considered significant. Results: The dogs had a neurological score (NS) of 3.6 +/- 0.5 and 3.4 +/- 0.5 in groups 1 and 2, respectively, in the early period (p > 0.05). In the late period, the dogs had an NS of 4.4 +/- 0.5 and 5.6 +/- 0.5 in groups 1 and 2, respectively (p < 0.05). The NS of each group differed significantly between the early and late period (p < 0.05). Early SPECT imaging showed 50 7.0% and 52 +/- 8.4% hypoperfusion corresponding to the left middle cerebral artery territory in groups 1 and 2, respectively (p > 0.05). In the late period, the degree of hypoperfusion decreased to 34 +/- 5.5% and 12 +/- 4.8% in groups 1 and 2, respectively (p < 0.05). The degree of hypoperfusion in both groups changed significantly between the early and late period (p < 0.05). In T-1- and T-2-weighted MRI images, the volume of the lesion in group 1 was significantly greater than in group 2 (p < 0.001). Conclusion: In our new ischemia model, simultaneous omental transposition is helpful in reversing the neurologic deficit and cerebral ischemic damage.en10.1159/000070612info:eu-repo/semantics/openAccessCerebral İschemiaOmental TranspositionSingle Photon Emission Computed TomographyMagnetic Resonance İmagingExperimental ModelArticle3538839412802102Q3WOS:000183887300010Q3