Karatoprak, Gökçe Şeker.Paşayeva, Leyla.Köngül Şafak, Esra.Göger, Fatih.Tugay, Osman.Koşar, Müberra.2020-03-262020-03-262019Karatoprak, G. Ş., Paşayeva, L., Şafak, E. K., Göger, F., Tugay, O., Koşar, M. (2019). Chemical Composition and Anti-Inflammatory Activity of Kitaibelia balansae Boiss. Farmacia, 67(6), 1054-1059.0014-82372065-0019https://dx.doi.org/10.31925/farmacia.2019.6.17https://hdl.handle.net/20.500.12395/37569Aerial part extracts of Kitaibelia balansae Boiss. were examined for their phenolic contents, as well as anti-inflammatory activities. The chemical compositions of the extracts were analysed by spectrophotometric and chromatographic (HPLC/ MS/MS and HPLC-PDA) approaches. To measure anti-inflammatory activity, the effects of the extracts on nitric oxide (NO) and Tumour Necrosis Factor-alpha (TNF-alpha) levels were measured in lipopolysaccharide (LPS) treated murine macrophage cell line (RAW 264.7). The ethyl acetate fraction was found to be abundant in phenolic compounds (259.78 +/- 15.07 mg(GAE)/gextract). Rutin was identified as the major compound in all the extracts. The ethyl acetate fraction potentially inhibited NO and TNF-alpha production (37.26 mu M and 1781.524 pg/mL, respectively, 6 h) in LPS induced cells.en10.31925/farmacia.2019.6.17info:eu-repo/semantics/openAccessKitaibelia balansaeMalvaceaeHPLC/MS/MSanti-inflammatoryArticle67610541059Q2WOS:000510208600017Q4